This policy setting determines whether Internet Explorer runs antimalware programs against ActiveX controls, to check if ...

This policy setting determines whether Internet Explorer runs antimalware programs against ActiveX controls, to check if they're safe to load on pages.
      
If you enable this policy setting, Internet Explorer won't check with your antimalware program to see if it's safe to create an instance of the ActiveX control.

If you disable this policy setting, Internet Explorer always checks with your antimalware program to see if it's safe to create an instance of the ActiveX control.

If you don't configure this policy setting, Internet Explorer always checks with your antimalware program to see if it's safe to create an instance of the ActiveX control. Users can turn this behavior on or off, using Internet Explorer Security settings.