The server selected for next hop could not be reached, or did not reply. A server selected as a proxy target for HTTP traffic ...

The server selected for next hop could not be reached, or did not reply.

A server selected as a proxy target for HTTP traffic could not be reached or did not reply: %1. 
Performance Counter Instance: %2 
Failure occurrences: %3, since %4. 
Failure Details: %5
Cause: The remote server may be experiencing problems or the network is not available between these servers.
Resolution:
Examine the event logs on the indicated server to determine the cause of the problem.
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