You can disable one or more network profiles by clearing the appropriate checkboxes (Domain/Private/Informal). However, if ...

You can disable one or more network profiles by clearing the appropriate checkboxes
        (Domain/Private/Informal). However, if all currently active profiles are unchecked,
        the configuration dialog disables the 'Configure remote debugging' button. For example,
        if your computer is connected to a single network, and this network is an Informal
        network, then unchecking the Informal checkbox will disable the Configure button.