You must create a spam quarantine mailbox before you can enable the feature. We recommend that you create a dedicated database ...

You must create a spam quarantine mailbox before you can enable the feature.  We recommend that you create a dedicated database for the spam quarantine mailbox. The spam quarantine mailbox should have a large database, because if the storage quota limit is reached, messages will be lost.  This step must be performed on a computer in the Exchange organization.
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